G-Protein Coupled Receptors (GPCRs) are integral membrane proteins that receive extracellular signals from the environment and transduce that signal to cause an effect within the cell. There are hundreds of different GPCRs, comprising of about 4% of the human genome. While there is a lot that is understood about how GPCRs work, the actual structure of an activated GPCR-G protein complex has never been solved, due to the difficulty of crystallization. Until now…
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